He must gently reprove those who oppose him, in the hope that God may grant them repentance leading to a knowledge of the truth.
In meekness instructing those that oppose themselves,.... To the truth; resist it and deny it; or contradict some other tenets and principles of theirs, or the Scriptures, which they themselves allowed to be the word of God, and the rule of faith and practice, and so are self-convinced and self-condemned. These are to be instructed, being ignorant, and in a tender and gentle manner, though very perverse and obstinate.
Be strengthened in grace, not as a permission to sloth, but as a command to shake off the flesh's sluggishness. Even the most gifted lose heart midway unless they are constantly aroused and reminded that their strength comes not from themselves but from Christ.
AI summary
Commenting on 2 Timothy 2:1-26
instructing--Greek, "disciplining," instructing with correction, which those who deal in "uninstructive" or "undisciplined questions" need (see on Ti2 2:23; Ti1 1:20). those that oppose themselves--Greek, "oppositely affected"; those of a different opinion. if . . . peradventure--Greek, "if at any time." repentance--which they need as antecedent to the full knowledge (so the Greek for 'acknowledgment') of the truth" (Ti1 2:4), their minds being corrupted (Ti2 3:8), and their lives immoral.