Then one said unto him, Behold, thy mother and thy brethren stand without, desiring to speak with thee.
Christ kept preaching to the crowd though interrupted by His mother and brothers outside, His work was not to be stopped by opposition or distraction. Note how those nearest to Him, with daily private access, were the least mindful to hear Him teach: familiarity breeds neglect of grace.
AI summary
Commenting on Matthew 12:46-50
Then one said unto him, Behold, thy mother and thy brethren stand without, desiring to speak with thee, &c.--Absorbed in the awful warnings He was pouring forth. He felt this to be an unseasonable interruption, fitted to dissipate the impression made upon the large audience--such an interruption as duty to the nearest relatives did not require Him to give way to.