Persecute and destroy them in anger from under the heavens of the LORD.
He first asks God to persecute them in wrath, that is, to be implacable to them; for persecution is, when God not only chastises the wicked for a short time, but when he adds evils to evils, and accumulates them until they perish.
Faith and fear wrestled in the Prophet's breast throughout this lament, but faith gets the last word. He found God heard his prayers even from the lowest dungeon; his weeping never hindered his praying. From such depths a man may find a way of access to God in the highest heavens.
AI summary
Commenting on Lamentations 3:55-66
from under . . . heavens of . . . Lord--destroy them so that it may be seen everywhere under heaven that thou sittest above as Judge of the world. Next: Lamentations Chapter 4