No stone shall be taken from you for a corner and no stone for a foundation, but you shall be a perpetual waste, declares the LORD.
He confirms the former verse, that when Babylon was destroyed, there would be no hope of restoration. It often happens, that those cities which have been wholly destroyed are afterwards built up again; but God says that this would not be the case with Babylon, for it was given over to perpetual destruction.
Babylon was once a golden cup in the Lord's hand, filled with His favor, but also His battle-axe to break nations. Those that carry all before them a great while will yet meet their match; even Babylon's day will come, and it too shall fall.
AI summary
Commenting on Jeremiah 51:1-58
Prepare against her the nations, with the kings of the Medes,.... At the head of them, Darius and Cyrus. The Syriac version has it in the singular number, the king of the Modes: the captains thereof, and all the rulers thereof, and all the land of his dominions; that is, the inhabitants of it, the common people, with their princes, nobles, governors, as captains of them, under Cyrus, their generalissimo.