Set your minds on things above, not on earthly things.
2. Not the things that are on earth. He does not mean, as he does a little afterwards, depraved appetites, which reign in earthly men, nor even riches, or fields, or houses, nor any other things of the present life, which we must use, as though we did not use them, (1 Corinthians 7:30, 31) See Calvin on the Corinthians, vol. 1, p. 257.
The apostle, having described our privileges by Christ in the former part of the epistle, and our discharge from the yoke of the ceremonial law, comes here to press upon us our duty as inferred thence. Though we are made free from the obligation of the ceremonial law, it does not therefore follow that we may live as we list.
Commenting on Colossians 3:1-4
Set your affections on things above,.... For unless the affections are set on them, they will never be sought after in a proper manner. The word signifies to mind them, and think on them, to favour and approve of them, to be affectionately desirous of them, and concerned for them; for where the treasure is, the heart should be; and as the saints' best things...